Hyaluronate Synthesis by Synovial Villi in Organ Culture
نویسندگان
چکیده
منابع مشابه
Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture.
Specimens of human rheumatoid and nonrheumatoid synovial lining were maintained in nonproliferative organ culture for 20 hours. The culture fluids were then assayed for prostaglandin E(2) (PGE(2)), thromboxane B(2) (TXB(2)), and 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)) by specific radioimmunoassay. The presence of each of these substances was confirmed by gas chromatography and mass ...
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Acute inflammation of joints can lead to the development of chronic arthritis. The nature of agents that sustain the chronic inflammation remains an enigma, although infectious agents such as Rubella virus, Epstein-Barr virus or Chlamydia have been invoked. In most cases in which an inducing agent was sought, none was found.' However, several antigens have been identified that elicit acute arth...
متن کاملDetermination of synovial fluid hyaluronate
High performance liquid chromatography (HPLC) with a size exclusion column and ultraviolet monitoring was used to study the effect of synovial fluid hyaluronate concentration and degree of polymerisation on viscosity and mucin clot formation. Rotational viscometry measurements showed an exponential relation between the synovial fluid hyaluronate concentration and relative viscosity, the viscosi...
متن کاملMode of formation of synovial villi.
Synovial tissue from 6 normal pigs and from 16 patients undergoing arthrotomy for joint disease was examined by dissecting microscopy. Scale models were constructed of 3 human synovial specimens from photographic magnifications of serial sections. Surface bridging and subintimal cavitation were observed, particularly in tissue from patients with rheumatoid arthritis. These features suggest that...
متن کاملHyaluronate in normal human synovial fluid.
Studies on hyaluronate in normal human synovial fluid have been hindered by the high viscosity and small volume of fluid available. Reports on hyaluronate levels in normal synovial fluid, in which a number of different methods have been used, have shown discordant results (1-4). Several methods were used in the present study to determine the hyaluronate content of normal synovial fluid. Weighin...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1983
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780260610